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KMID : 0614020020170010061
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Journal of Pharmaceutical Sciences (C.N.U.)
2002 Volume.17 No. 1 p.61 ~ p.67
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Effects of ascorbic acid of in vitro Methods on the phototoxicity of phenothia
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Kim Jong-Yea
Kim Hyun-Jin
Kim Bong-Hee
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Abstract
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The effects of ascorbic acid a well-known as antioxidant agent, on the phototoxicity caused by phenothiazines were studied using three in vitro methods - MTT assay, the Candida test, and the RBC photohemolysis. The tested phenothiazines include Chlorpromazine, Promethazine, Perphenazine, Chlorprothixene, Trifluoperazine, and Thioridazine and UVA 1.5 J/㎠ were irradiated. In results, ascorbic acid was effective to reduce the phototoxicities and to decrease the production of toxic photoproducts in every method used.
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KEYWORD
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Ascorbic acid, phototoxicity, phenothiazines, MTT assay, Candida test, photohemolysis
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